ABSTRACT
Effective control of tuberculosis (TB) requires an understanding of the changing epidemiology
of the disease. An understanding of the epidemiology is needed for public health departments
to respond with appropriate program-planning decisions. Following a marked decline
in the incidence of tuberculosis in the United States over several decades, the incidence
escalated dramatically and peaked in 1992. The resurgence of TB reflected several
factors, including deteriorating social conditions, dismantling of the public health
infrastructure, dwindling support for tuberculosis clinics and services, the new epidemic
of HIV/AIDS with highly susceptible individuals at risk, and immigration of individuals
from countries with high rates of TB. Since 1992, there has been a substantial decline
in new cases. The success in reducing the tuberculosis burden reflects several factors,
including improved public health efforts, physician and patient education, infection
control measures, and the use of directly observed therapy (DOT). By 2006, cases of
TB in the United States had reached historic lows. Currently, a majority of cases
of TB occur in foreign-born individuals, reflecting immigration from countries with
high endemic rates of TB. Future efforts to curtail the incidence of TB will require
vigilant public health efforts, improving education of patients and health care personnel,
identifying mechanisms and routes of transmission, and assuring adequate treatment
and prophylactic regimens among infected individuals.
KEYWORDS
Tuberculosis - epidemiology - United States -
Mycobacterium tuberculosis
- public health
REFERENCES
- 1
Taylor Z, Nolan C M, Blumberg H M.
Controlling tuberculosis in the United States. Recommendations from the American Thoracic
Society, CDC, and the Infectious Diseases Society of America.
MMWR Recomm Rep.
2005;
54
1-81
- 2
Frieden T R, Lerner B H, Rutherford B R.
Lessons from the 1800s: tuberculosis control in the new millennium.
Lancet.
2000;
355
1088-1092
- 3
Diagnostic standards and classification of tuberculosis in adults and children.
Am J Respir Crit Care Med.
2000;
161
1376-1395
- 4 Dubos R, Dubos J. The White Plague. Boston; Little, Brown 1952
- 5
Brudney K, Dobkin J.
Resurgent tuberculosis in New York City: human immunodeficiency virus, homelessness,
and the decline of tuberculosis control programs.
Am Rev Respir Dis.
1991;
144
745-749
- 6
Sidel V W, Drucker E, Martin S C.
The resurgence of tuberculosis in the united states: societal origins and societal
responses.
J Law Med Ethics.
1993;
21
303-316
- 7
Frieden T R, Sterling T, Pablos-Mendez A, Kilburn J O, Cauthen G M, Dooley S W.
The emergence of drug-resistant tuberculosis in New York City.
N Engl J Med.
1993;
328
521-526
- 8
Gandhi N R, Moll A, Sturm A W et al..
Extensively drug-resistant tuberculosis as a cause of death in patients co-infected
with tuberculosis and HIV in a rural area of South Africa.
Lancet.
2006;
368
1575-1580
- 9
Kremer K, van Soolingen D, Frothingham R et al..
Comparison of methods based on different molecular epidemiological markers for typing
of Mycobacterium tuberculosis complex strains: interlaboratory study of discriminatory power and reproducibility.
J Clin Microbiol.
1999;
37
2607-2618
- 10
van Embden J D, van Soolingen D, Small P M, Hermans P W.
Genetic markers for the epidemiology of tuberculosis.
Res Microbiol.
1992;
143
385-391
- 11
Van Soolingen D.
Molecular epidemiology of tuberculosis and other mycobacterial infections: main methodologies
and achievements.
J Intern Med.
2001;
249
1-26
- 12
van Soolingen D, Hermans P W, de Haas P E, Soll D R, van Embden J D.
Occurrence and stability of insertion sequences in mycobacterium tuberculosis complex
strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool
in the epidemiology of tuberculosis.
J Clin Microbiol.
1991;
29
2578-2586
- 13
Daley C L, Small P M, Schecter G F et al..
An outbreak of tuberculosis with accelerated progression among persons infected with
the human immunodeficiency virus: an analysis using restriction-fragment-length polymorphisms.
N Engl J Med.
1992;
326
231-235
- 14
Small P M, Hopewell P C, Singh S P et al..
The epidemiology of tuberculosis in San Francisco: a population-based study using
conventional and molecular methods.
N Engl J Med.
1994;
330
1703-1709
- 15
Alland D, Kalkut G E, Moss A R et al..
Transmission of tuberculosis in New York City: an analysis by DNA fingerprinting and
conventional epidemiologic methods.
N Engl J Med.
1994;
330
1710-1716
- 16
Geng E, Kreiswirth B, Burzynski J, Schluger N W.
Clinical and radiographic correlates of primary and reactivation tuberculosis: a molecular
epidemiology study.
JAMA.
2005;
293
2740-2745
- 17
Frieden T R, Fujiwara P I, Washko R M, Hamburg M A.
Tuberculosis in New York City—turning the tide.
N Engl J Med.
1995;
333
229-233
- 18
CDC .
Trends in tuberculosis incidence–United States, 2006.
MMWR Morb Mortal Wkly Rep.
2007;
56
245-250
- 19
Trends in tuberculosis—United States, 2007.
MMWR Morb Mortal Wkly Rep.
2008;
57
281-285
- 20
Muga R, Ferreros I, Langohr K et al..
Changes in the incidence of tuberculosis in a cohort of HIV-seroconverters before
and after the introduction of HAART.
AIDS.
2007;
21
2521-2527
- 21
Moh R, Danel C, Messou E et al..
Incidence and determinants of mortality and morbidity following early antiretroviral
therapy initiation in HIV-infected adults in West Africa.
AIDS.
2007;
21
2483-2491
- 22
Albalak R, O'Brien R J, Kammerer J S et al..
Trends in tuberculosis/human immunodeficiency virus comorbidity, United States, 1993–2004.
Arch Intern Med.
2007;
167
2443-2452
- 23
Zabana Y, Domenech E, San Roman A L et al..
Tuberculous chemoprophylaxis requirements and safety in inflammatory bowel disease
patients prior to anti-TNF therapy.
Inflamm Bowel Dis.
2008;
, May 1 [Epub ahead of print]
- 24
Leung C C, Lam T H, Chan W M et al..
Diabetic control and risk of tuberculosis: a cohort study.
Am J Epidemiol.
2008;
167
1486-1494
- 25
Cain K P, Haley C A, Armstrong L R et al..
Tuberculosis among foreign-born persons in the united states: achieving tuberculosis
elimination.
Am J Respir Crit Care Med.
2007;
175
75-79
- 26
Geng E, Kreiswirth B, Driver C et al..
Changes in the transmission of tuberculosis in New York City from 1990 to 1999.
N Engl J Med.
2002;
346
1453-1458
- 27
Walter N D, Jasmer R M, Grinsdale J, Kawamura L M, Hopewell P C, Nahid P.
Reaching the limits of tuberculosis prevention among foreign-born individuals: a tuberculosis-control
program perspective.
Clin Infect Dis.
2008;
46
103-106
- 28
Dahle U R, Eldholm V, Winje B A, Mannsaker T, Heldal E.
Impact of immigration on the molecular epidemiology of Mycobacterium tuberculosis in a low-incidence country.
Am J Respir Crit Care Med.
2007;
176
930-935
- 29
Brodie D, Lederer D J, Gallardo J S, Trivedi S H, Burzynski J N, Schluger N W.
Use of an interferon-gamma release assay to diagnose latent tuberculosis infection
in foreign-born patients.
Chest.
2008;
133
869-874
- 30
Menzies D, Pai M, Comstock G.
Meta-analysis: new tests for the diagnosis of latent tuberculosis infection: areas
of uncertainty and recommendations for research.
Ann Intern Med.
2007;
146
340-354
- 31
Andrews J R, Shah N S, Gandhi N, Moll T, Friedland G.
Multidrug-resistant and extensively drug-resistant tuberculosis: implications for
the HIV epidemic and antiretroviral therapy rollout in South Africa.
J Infect Dis.
2007;
196(Suppl 3)
S482-S490
- 32
Wells C D, Cegielski J P, Nelson L J et al..
Hiv infection and multidrug-resistant tuberculosis: the perfect storm.
J Infect Dis.
2007;
196(Suppl 1)
S86-S107
- 33
Matteelli A, Migliori G B, Cirillo D, Centis R, Girard E, Raviglion M.
Multidrug-resistant and extensively drug-resistant Mycobacterium tuberculosis: epidemiology and control.
Expert Rev Anti Infect Ther.
2007;
5
857-871
- 34
Bai G H, Park Y K, Choi Y W et al..
Trend of anti-tuberculosis drug resistance in Korea, 1994–2004.
Int J Tuberc Lung Dis.
2007;
11
571-576
- 35
Blondal K.
Barriers to reaching the targets for tuberculosis control: multidrug-resistant tuberculosis.
Bull World Health Organ.
2007;
85
387-390
discussion 391-384
- 36
Zignol M, Hosseini M S, Wright A et al..
Global incidence of multidrug-resistant tuberculosis.
J Infect Dis.
2006;
194
479-485
- 37
Yerokhin V V, Punga V V, Rybka L N.
Tuberculosis in Russia and the problem of multiple drug resistance.
Ann N Y Acad Sci.
2001;
953
133-137
- 38
Fujiwara P I, Cook S V, Rutherford C M et al..
A continuing survey of drug-resistant tuberculosis, New York City, April 1994.
Arch Intern Med.
1997;
157
531-536
- 39 Healthy People 2010. Washington, DC; Office of Health Promotion and Preventive
Services, Department of Health and Human Services 2000
- 40
Schwartzman K, Oxlade O, Barr R G et al..
Domestic returns from investment in the control of tuberculosis in other countries.
N Engl J Med.
2005;
353
1008-1020
- 41
Khan K, Wang J, Hu W, Bierman A, Li Y, Gardam M.
Tuberculosis infection in the United States: national trends over three decades.
Am J Respir Crit Care Med.
2008;
177
455-460
- 42
Bennett D E, Courval J M, Onorato I et al..
Prevalence of tuberculosis infection in the United States population: the National
Health and Nutrition Examination Survey, 1999–2000.
Am J Respir Crit Care Med.
2008;
177
348-355
- 43
Bates M N, Khalakdina A, Pai M, Chang L, Lessa F, Smith K R.
Risk of tuberculosis from exposure to tobacco smoke: a systematic review and meta-analysis.
Arch Intern Med.
2007;
167
335-342
Neil W SchlugerM.D.
Columbia University Medical Center, PH-8 East, Rm. 101, 622 W. 168th St.
New York, NY 10032
Email: ns311@columbia.edu